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Chemokines and lymphocyte biology
1Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA. hedrick@dnax.org
Current Opinion in Immunology
|June 1, 1996
Summary
Chemokines, signaling proteins, are increasingly recognized for roles beyond leukocyte movement. These molecules also appear to regulate lymphocyte growth, activation, and differentiation.
Area of Science:
- Immunology
- Cell Biology
Background:
- Significant growth in the number of known chemokines.
- Expanding understanding of chemokine functions beyond leukocyte chemotaxis.
Purpose of the Study:
- To explore the emerging roles of chemokines in lymphocyte regulation.
- To investigate chemokines as products of activated lymphocytes.
Main Methods:
- Literature review and analysis of recent findings in chemokine research.
Main Results:
- Chemokines are major products of activated lymphocytes.
- Some chemokines regulate lymphocyte growth, activation, and differentiation.
Conclusions:
- Chemokines possess multifaceted roles in immune responses.
- Further research into chemokine functions in lymphocyte biology is warranted.