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Primary and secondary immune responses to Listeria monocytogenes
J T Harty1, L L Lenz, M J Bevan
1Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA. john-harty@uiowa.edu
Current Opinion in Immunology
|August 1, 1996
Abstract:
Recent studies have revealed the complexity of cytokine and cellular interactions required for resistance to primary Listeria monocytogenes infection and have illustrated that resistance to secondary infection may occur through multiple pathways. Analyses of Listeria epitope generation and the specificity of protective CD8(+) T cells have suggested that future research should focus on secreted protein antigens in specific resistance to infection and have increased our understanding of Listeria antigens presented by MHC class l-b molecules.