Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Macaque models for AIDS vaccine development

R P Johnson1

  • 1New England Regional Primate Research Center, Harvard Medical School, PO Box 9102, One Pine Hill Drive, Southborough, MA 01772, USA. pjohnson@warren.med.harvard.edu

Current Opinion in Immunology
|August 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a breathing lung phantom for proton CT imaging.

Physics in medicine and biology·2025
Same author

Demonstration of active neutron interrogation of special nuclear materials using a high-intensity short-pulse-laser-driven neutron source.

Scientific reports·2025
Same author

Iatrogenic urinary injuries in colorectal surgery: outcomes and risk factors from a nationwide cohort.

Techniques in coloproctology·2024
Same author

The accuracy of helium ion CT based particle therapy range prediction: an experimental study comparing different particle and x-ray CT modalities.

Physics in medicine and biology·2021
Same author

Experimental realization of dynamic fluence field optimization for proton computed tomography.

Physics in medicine and biology·2020
Same author

An optimization algorithm for dose reduction with fluence-modulated proton CT.

Medical physics·2020
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Recent AIDS vaccine research in macaques suggests antibodies neutralizing viruses are key for protection. This indicates new benchmarks for effective AIDS vaccines may be needed, even without sterilizing immunity.

Area of Science:

  • Immunology
  • Virology
  • Vaccinology

Background:

  • The simian immunodeficiency virus (SIV)/macaque model is crucial for studying AIDS pathogenesis and vaccine efficacy.
  • Understanding mechanisms of protective immunity is vital for developing an effective human immunodeficiency virus (HIV) vaccine.

Purpose of the Study:

  • To investigate the correlates of protective immunity in recent SIV vaccine trials using the macaque model.
  • To evaluate the roles of different immune responses, such as cytotoxic T lymphocytes and antibodies, in protection against SIV infection and AIDS.

Main Methods:

  • Analysis of data from simian immunodeficiency virus (SIV) vaccine trials in macaques.
  • Assessment of cytotoxic T lymphocyte (CTL) responses to SIV antigens.
  • Measurement of neutralizing antibody responses against primary and heterologous pathogenic viruses.

Related Experiment Videos

Main Results:

  • While cytotoxic T lymphocyte responses to SIV may contribute to protection, they do not appear to be the primary correlate.
  • The development of antibodies capable of neutralizing pathogenic simian immunodeficiency viruses (SIVs) strongly correlates with protective immunity.
  • Protection against simian immunodeficiency virus (SIV)-induced disease or persistent infection can be achieved without achieving sterilizing immunity.

Conclusions:

  • Antibody-mediated neutralization of pathogenic viruses is a critical component of protective immunity in the SIV/macaque model.
  • The findings suggest that current benchmarks for AIDS vaccine efficacy, which often aim for sterilizing immunity, may need re-evaluation.
  • New benchmarks focusing on protection against disease and persistent infection, rather than complete viral eradication, should be considered for future AIDS vaccine development.