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Patterning the hindbrain

¹Department of Developmental Neurobiology, UMDS, Guy's Hospital, London, UK. s.guthrie@umds.ac.uk

Current Opinion in Neurobiology

|February 1, 1996

Summary

This summary is machine-generated.

Retinoic acid establishes rostrocaudal domains in the hindbrain, specifying rhombomere identity. These domains interact with dorsoventral signals, refining cell fates and enabling neural crest development.

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Area of Science:

Developmental biology
Neuroscience
Genetics

Background:

Hindbrain patterning relies on rostrocaudal positional information.
Retinoic acid is implicated in establishing gene expression domains along this axis.

Purpose of the Study:

To investigate the role of retinoic acid in specifying hindbrain rhombomere identity.
To understand how rostrocaudal domains interact with dorsoventral signals.

Main Methods:

Analysis of gene expression patterns in the developing hindbrain.
Investigating the effects of retinoic acid on rhombomere development.
Studying neural crest formation in relation to hindbrain patterning.

Main Results:

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Retinoic acid establishes distinct rostrocaudal domains influencing rhombomere identity.

These domains exhibit differential responses to dorsoventral signals.

Segmental interactions along the rostrocaudal axis persist after boundary formation, crucial for neural crest generation.

Conclusions:

Retinoic acid is a key factor in rostrocaudal patterning of the hindbrain.
A combination of rostrocaudal and dorsoventral signaling refines hindbrain cell fates.
Segmental autonomy and rostrocaudal interactions are balanced during hindbrain development.