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Updated: Jul 28, 2026

Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor
Published on: June 14, 2011
Engineering and design of blood substitutes
K E Sanders1, G Ackers, S Sligar
1Beckman Institute, 405 North Mathews, Urbana, Illinois 61801, USA.
Abstract:
Clinical experiences with chemically modified and genetically engineered hemoglobin blood substitutes have uncovered new side-effects that must be addressed before a viable oxygen-carrying alternative to blood can be developed. These include, among others, vasoactivity and rapid autoxidation resulting in free-radical-mediated toxicity. Research is now being directed towards understanding the mechanisms of these toxic side-effects and developing methods of overcoming them.
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