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Related Experiment Videos

Living donor transplants

J M Cecka1

  • 1UCLA Tissue Typing Laboratory, Los Angeles, California, USA.

Clinical Transplants
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Living donor kidney transplants show high graft survival rates, with HLA-identical sibling transplants offering the best long-term outcomes. Older living donors also demonstrate favorable survival rates, comparable to younger donors.

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Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Organ Donation

Background:

  • Living donor kidney transplantation has seen a significant increase in reported cases.
  • Nearly all US transplant centers perform living donor transplants, indicating widespread adoption.
  • Graft survival rates for living donor transplants are consistently high across various donor types.

Purpose of the Study:

  • To analyze the outcomes of living donor kidney transplants.
  • To compare graft survival rates across different donor relationships (sibling, parent, unrelated).
  • To evaluate the impact of donor age and recipient sensitization on transplant success.

Main Methods:

  • Analysis of data reported to the UNOS Scientific Renal Transplant Registry.
  • Calculation of one- and five-year graft survival rates and transplant half-lives.

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  • Comparison of outcomes based on donor type, HLA matching, recipient race, and donor age.

    • Main Results:

    • One- and 5-year graft survival rates ranged from 84-95% and 69-84%, respectively.
    • Transplant half-lives were significantly better for living donor grafts (up to 22 years for HLA-identical siblings) compared to projected cadaveric grafts (9 years).
    • Outcomes were comparable across different donor relationships, but causes of graft failure varied. Older donors (over 60) showed slightly lower survival rates (86% 1-year, 61% 5-year) than younger donors (90% 1-year, 72% 5-year).

    Conclusions:

    • Living donor kidney transplantation offers excellent and durable graft survival.
    • HLA-identical sibling donors provide the best long-term graft survival.
    • Donor age is a factor, but older donors still provide viable grafts, and pretransplant transfusions did not improve outcomes.