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Age-related morphological changes in the hippocampus in two mouse strains
M Barkats1, J Y Bertholet, C Cohen-Salmon
1Neurogénétique et Comportement, URA 1294 CNRS, Paris, France.
Mechanisms of Ageing and Development
|June 25, 1996
Summary
Genetic factors influence how the dentate gyrus (DG) ages. Different mouse strains show varied changes in granule cell number (nGR) with age, suggesting hereditary impacts on brain aging.
Area of Science:
- Neuroscience
- Genetics
- Aging Research
Background:
- Granule cell number (nGR) in the dentate gyrus (DG) varies significantly across mouse strains, indicating genetic influence.
- Age-related structural changes in the DG are documented but lack consistent findings in scientific literature.
Purpose of the Study:
- To investigate strain-specific differences in hippocampal structure, focusing on the dentate gyrus, between young and old mice.
- To compare age-related changes in granule cell number (nGR) in C57BL/6J (B) and DBA/2J (D) mouse strains.
Main Methods:
- Determined nGR and other hippocampal structural parameters in female B and D mice at 4 and 24 months of age.
- Utilized two-way analysis of variance to analyze the interaction between 'strain' and 'age' for nGR.
Main Results:
- A significant interaction between 'strain' and 'age' was observed for nGR.
- This interaction indicates that nGR changes differently with age in the B and D mouse strains.
Conclusions:
- Mouse strains exhibit differential susceptibility to age-related changes in granule cell number.
- Hereditary factors likely influence the aging process of the granule cell population in the dentate gyrus.