Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxygen uptake following deep hypothermia

T R Abbott

    Anaesthesia
    |June 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    During deep hypothermia, initial oxygen uptake (Vo2) in children with congenital heart disease was high but normalized quickly. This suggests dissolved oxygen may protect tissues during circulatory arrest.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of growth and development on abnormal labial frenum.

    American journal of diseases of children (1911)·2010
    Same author

    Effect of temperature and cardiopulmonary bypass on the auditory evoked response.

    British journal of anaesthesia·1995
    Same author

    Case 3--1994. Management of postoperative tracheomalacia in an 11-year-old boy.

    Journal of cardiothoracic and vascular anesthesia·1994
    Same author

    Kinking of a Seldinger wire.

    Anaesthesia·1989
    Same author

    Selectatec system: misplaced blood.

    Anaesthesia·1986
    Same author

    Hypothermic cardiopulmonary bypass in a patient with sickle-cell trait.

    Anaesthesia·1984

    Area of Science:

    • Cardiovascular Surgery
    • Pediatric Cardiology
    • Physiology

    Background:

    • Congenital heart lesions often require surgical correction.
    • Cardiopulmonary bypass with deep hypothermia and circulatory arrest is a critical procedure.
    • Understanding tissue oxygenation during arrest is vital for patient outcomes.

    Purpose of the Study:

    • To measure oxygen uptake (Vo2) in children during surgical correction of congenital heart lesions.
    • To investigate the role of dissolved oxygen in tissues during deep hypothermia and circulatory arrest.

    Main Methods:

    • Measured oxygen uptake (Vo2) in 9 children.
    • Utilized cardiopulmonary bypass and deep hypothermia (20°C) with circulatory arrest.
    • Monitored Vo2 levels during and after circulatory arrest.

    Related Experiment Videos

    Main Results:

    • Initial Vo2 levels were four times higher than expected post-circulatory arrest.
    • Vo2 levels normalized within 8-10 minutes.
    • The measured oxygen uptake correlated with theoretical values for physically dissolved oxygen at 20°C.

    Conclusions:

    • Elevated dissolved oxygen in tissues may mitigate damage during circulatory arrest in deep hypothermia.
    • This finding has implications for optimizing perfusion strategies in pediatric cardiac surgery.
    • Further research is warranted to confirm the protective role of dissolved oxygen.