Potassium depletion and tissue loss in chronic heart-disease

Weight-loss, total body-potassium, and total body-nitrogen were measured in 12 men and 15 women with severe chronic heart-disease. Compared with age-matched healthy controls, the men had lost an average of 13 kg in weight, 915 mmol of potassium, and 354 g of nitrogen, whereas the women had lost 5.6 kg of weight, 327 mmol of potassium, and 66 g of nitrogen. Although the potassium/nitrogen ratio in the lost tissue is not precisely known, the loss of nitrogen indicates that most of the potassium loss in men is due to tissue loss and that there is little fall in the intracellular concentration of potassium in either the men or the women.