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Published on: January 26, 2018
Pseudotumor cerebri associated with cyclosporine use
O A Cruz1, S G Fogg, G Roper-Hall
1Anheuser-Busch Eye Institute, St. Louis University School of Medicine, MO, USA. CRUZOA@SLUVCA.SLV.EDU
American Journal of Ophthalmology
|September 1, 1996
Summary
Cyclosporine, a medication used after bone marrow transplants, can cause pseudotumor cerebri. This condition led to double vision and optic nerve swelling in a child, which resolved after stopping the drug.
Area of Science:
- Ophthalmology
- Neurology
- Pediatrics
Background:
- Allogeneic bone marrow transplantation is a life-saving procedure but can lead to complications like graft-versus-host disease.
- Graft-versus-host disease and its treatments, including immunosuppressants, can have diverse systemic effects.
Observation:
- An 11-year-old boy presented with a one-month history of horizontal diplopia and esotropia.
- Examination revealed bilateral optic disc edema, and lumbar puncture showed elevated opening pressure (500 mm H2O).
- No intracranial lesions were identified on magnetic resonance imaging.
Findings:
- A diagnosis of pseudotumor cerebri secondary to cyclosporine use was made.
- Discontinuation of cyclosporine resulted in rapid improvement of esotropia and diplopia within five days.
- Optic disc edema resolved completely within three months of cyclosporine cessation.
Implications:
- Cyclosporine should be recognized as a potential cause of pseudotumor cerebri.
- This case highlights the importance of considering medication side effects in pediatric patients with neurological and ophthalmological symptoms.
- Early recognition and management of drug-induced pseudotumor cerebri can prevent long-term visual impairment.
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