Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Midazolam co-induction and laryngeal mask insertion

I K Driver1, S Wiltshire, P Mills

  • 1Department of Anaesthesia, Ipswich Hospital, Suffolk.

Anaesthesia
|August 1, 1996
PubMed
Summary

Midazolam and alfentanil combined with propofol improved conditions for laryngeal mask airway insertion. This combination reduced propofol requirements and patient responses during anesthesia induction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary Artery Stenting for Widespread Distal Congenital Stenoses.

JACC. Case reports·2025
Same author

Relieving veterinarians' workloads and stress: leveraging Australia's veterinary technologists and nurses.

Australian veterinary journal·2023
Same author

Predictors of in-hospital mortality in HIV-infected patients with COVID-19.

QJM : monthly journal of the Association of Physicians·2022
Same author

Comparative Pharmacokinetics and Local Tolerance of Tenofovir Alafenamide (TAF) From Subcutaneous Implant in Rabbits, Dogs, and Macaques.

Frontiers in pharmacology·2022
Same author

Safety and efficacy of a biodegradable implant releasing tenofovir alafenamide for vaginal protection in a macaque model.

The Journal of antimicrobial chemotherapy·2022
Same author

Controlled-release opioids cause harm and should be avoided in management of postoperative pain in opioid naïve patients.

British journal of anaesthesia·2019

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Propofol is commonly used for anesthesia induction.
  • Optimizing conditions for laryngeal mask airway (LMA) insertion is crucial for patient safety and procedural success.

Purpose of the Study:

  • To evaluate the effects of alfentanil and midazolam+alfentanil on LMA insertion conditions during propofol-induced anesthesia.
  • To compare the efficacy of different pre-anesthetic medication regimens.

Main Methods:

  • A randomized study involving 90 ASA 1 or 2 adult patients.
  • Three groups received different combinations: propofol only, alfentanil followed by propofol, or midazolam and alfentanil followed by propofol.
  • Propofol dosage was adjusted based on anesthetic induction adequacy.

Main Results:

Related Experiment Videos

  • The midazolam+alfentanil group required significantly less propofol (p < 0.001).
  • This group also demonstrated superior mouth opening (p < 0.001).
  • Fewer undesired responses to LMA insertion were observed in the midazolam+alfentanil group (p < 0.001).

Conclusions:

  • Pre-administration of midazolam and alfentanil enhances conditions for laryngeal mask airway insertion.
  • This combination reduces overall propofol requirements and improves patient tolerance during anesthesia induction.