Potential anti-diabetic applications of a new molecule with affinity for beta 3-adrenoceptors

M Barrionuevo¹, F I Milagro, E Cenarruzabeitia

¹Department of Pharmacology, University of Navarra, Pamplona, Spain.

|January 1, 1996

Abstract:

beta 3-adrenoceptors have been described through both molecular and pharmacological studies. In this context, it has been characterized the beta 3-adrenoceptor agonist activity of a new compound (Trecadrine), and evaluated whether it exhibits additional activity at beta 1- and beta 2-adrenoceptor subtypes. In addition, it has been tested its potential anti-diabetic properties in a model of alloxan-induced diabetes in rats. Our data show that Trecadrine induces oesophageal muscularis mucosae relaxation, indicating a putative action on beta 3-adrenoceptors. In the absence of beta 3-adrenoceptor antagonists, assays with beta 1- and beta 2-adrenergic antagonists reveal a quite remarkable selectivity for beta 3-adrenoceptors. Furthermore, it has been suggested that this molecule has hypoglycaemic and lipomobilizing effects, although hypoglycaemia was not related to an increase in insulin secretion in diabetic rats. It is concluded that Trecadrine mainly acts through beta 3-adrenoceptors, and it may constitute a potential drug in the treatment of diabetes.

Related Experiment Videos

Potential anti-diabetic applications of a new molecule with affinity for beta 3-adrenoceptors

Related Concept Videos

Editorial Special Issue: 2021 consortium for trans-pyrenean investigations on obesity and diabetes.

Fatty acids, epigenetic mechanisms and chronic diseases: a systematic review.

Involvement of autophagy in the beneficial effects of resveratrol in hepatic steatosis treatment. A comparison with energy restriction.

Regulatory roles of miR-155 and let-7b on the expression of inflammation-related genes in THP-1 cells: effects of fatty acids.

Effect of hypoxia on caveolae-related protein expression and insulin signaling in adipocytes.

Differential lipid metabolism outcomes associated with ADRB2 gene polymorphisms in response to two dietary interventions in overweight/obese subjects.

ROS-xCT metabolic coupling defines an astrocyte subtype that drives glutamate excitotoxicity during Alzheimer's disease progression.

Electrophysiological and computational analyses of anethole-induced inhibition of L-type calcium channels in rat tracheal smooth muscle.

In vivo pharmacokinetics and lactic acidosis toxicity of Phenformin mediated by gut microbiota in control and pseudo-germ-free rats.

The spike protein S1 of SARS-CoV-2 promotes Th17 cell-dependent stress-induced depressive-like behaviors in mice.

TRPV4 deletion remodels the gut microbiota and increases colonic ammonia levels.

Cyclo(Val-Pro) and cyclo(Phe-Phe) alleviate MASLD via distinct CCR2- and ADCY7-associated pathways.

Comparative characterization of candidal cell surface-associated phosphoglycerate mutase (Gpm1) - fungal cell wall adsorption and host protein binding across pathogenic Candida species.

Spectrum-effect relationship between chromatography fingerprints and bioactive components of Atractylodes macrocephala on alleviating ulcerative colitis.

Dominant doubly charged ion enabling robust LC-MS/MS quantification of a novel small-molecule antibacterial drug Cefidelbaz in human plasma and its application to pharmacokinetic and protein binding studies.

When dying worms look alike: Convergent pathology may create mechanistic illusion in plant-derived anthelmintic research.

Structural and Mechanistic Studies of ADEPs Yield Potent Antibacterials and a Drug Formulation Strategy for Tuberculosis.

Related Experiment Videos

Potential anti-diabetic applications of a new molecule with affinity for beta 3-adrenoceptors

Abstract:

Related Concept Videos

Related Articles