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Related Experiment Videos

Feline factor XII (Hageman) deficiency

R A Green, F White

    American Journal of Veterinary Research
    |June 1, 1977
    PubMed
    Summary

    A feline coagulation disorder was identified, showing prolonged activated partial thromboplastin time. This study confirmed factor XII deficiency as the cause in a clinically normal cat.

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    Area of Science:

    • Veterinary Hematology
    • Coagulation Science

    Background:

    • Coagulation disorders can present subtly in animals.
    • Intrinsic pathway defects affect specific clotting factors.

    Purpose of the Study:

    • To investigate an unexplained intrinsic coagulation defect in a clinically normal cat.
    • To identify the specific coagulation factor deficiency.

    Main Methods:

    • Performed a comprehensive coagulation profile including activated partial thromboplastin time (aPTT), bleeding time, and platelet count.
    • Conducted correction studies using aPTT to pinpoint the deficient factor.
    • Performed hematologic and clinical evaluations to rule out secondary causes.

    Main Results:

    • The cat exhibited a prolonged aPTT with normal bleeding time, platelet count, and prothrombin time.
    • Correction studies confirmed factor XII deficiency.
    • No underlying disease process for acquired factor XII deficiency was identified.

    Conclusions:

    • The cat has an intrinsic coagulation defect consistent with congenital factor XII deficiency.
    • Factor XII deficiency may not present with overt clinical signs in all cases.
    • This case highlights the importance of thorough coagulation testing in apparently healthy animals.

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