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Updated: Aug 10, 2026
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Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
Published on: January 7, 2013
Cyclosporine A decreases kallikrein and BK2 mRNA expression in the rat renal cortex
G Bompart1, I Tack, E Marin Castaño
1INSERM U388 Institut Louis Bugnard, CHU Rangueil, Toulouse, France.
Immunopharmacology
|May 1, 1996
Abstract:
The effect of subcutaneous injection of cyclosporine (20 mg/kg/day for 3 days) on the expression of kallikrein (Kal) and bradykinin 2 receptor (BK2) mRNA in the rat renal cortex was examined. CsA decreased significantly Kal and BK2 mRNA expression in the kidney cortex. These results indicate that the kallikrein-kinin system may participate in the genesis or the aggravation of the renal haemodynamic effect induced by long term administration of CsA.
