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Synthetic inhibitors of human tissue kallikrein
D M Evans1, D M Jones, G R Pitt
1Ferring Research Institute, University of Southampton Research Centre, UK.
Immunopharmacology
|May 1, 1996
Abstract:
We have developed a series of novel, potent low molecular weight (4-600 Da) inhibitors of TK which were stable to cleavage by the enzyme and showed a high degree of selectivity for TK over several other serine proteases. Compound 7 (CH-2856) was found to reduce eosinophilia in a model of allergic inflammation. The effects observed in vivo provide further evidence for the involvement of TK and kinins in the pathophysiology of allergic diseases such as asthma.