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Histamine receptors and bioeffects on clonal parathyroid endothelial cells
U Frediani1, S Benvenuti, L Masi
1Dipartimento di Fisiopatologia Clinica e, University of Firenze, Italy.
Journal of Endocrinological Investigation
|May 1, 1996
Abstract:
Using a clonal line of bovine parathyroid endothelial cells (BPE-1) we defined the presence on these cells of a histamine H2 receptor and characterized its pharmacological properties. Interaction of histamine with its receptor induced an increase of cAMP accumulation in a dose- and time-dependent fashion. This effect appears unique for parathyroid endothelial cells, in fact, clonal parathyroid epithelial cells did not exhibit a similar response. No effect of histamine was observed on BPE-1 cell proliferation.