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Hyperthermia complicating tricyclic antidepressant overdose
P Hantson1, M Benaissa, J L Clemessy
1Réanimation Toxicologique, Hôpital Fernand Widal, Paris, France.
Intensive Care Medicine
|May 1, 1996
Abstract:
We observed a 51-year-old woman who was admitted for severe amitriptyline overdose. Besides major cardiovascular complications, the patient developed severe hyperpyrexia with a central body temperature of more than 43 degrees C for 5 h. The patient died on day 3 from cardiocirculatory collapse and arrhythmias. Hyperthermia was unresponsive to cooling with ice water, gastric lavage, muscle relaxation, and dantrolene and bromocriptine administration. The possible mechanisms of refractory hyperthermia are discussed.