Related Experiment Videos
Effects of magnetic resonance imaging on polymorphonuclear neutrophil functions
A Minczykowski1, W Paprzycki, J Smielecki
1Department of Intensive Therapy, Karol Marcinkowski University School of Medical Sciences, Poznan, Poland.
Rationale And Objectives:
Limited research has been performed on the effects of magnetic resonance (MR) imaging on the immune system. To our knowledge, there are no reported studies of MR imaging effects on the polymorphonuclear neutrophil (PMN) system. Therefore, we evaluated the influence of MR imaging exposure on PMNs.
Methods:
In vivo and in vitro studies were performed on 36 patients undergoing MR imaging. The following were estimated in blood samples: leukocyte and PMN count, PMN phagocytosis and bactericidal capacity, percentage of cells with expression of surface receptor for the Fc fragment of immunoglobulin G (IgG), PMN superoxide, hydrogen peroxide production, and plasma lysozyme activity. Another sample of patients was used to eliminate temperature as an influence on changes in PMN functions.
Results:
Both in vitro and in vivo MR imaging led to a decrease in PMNs and an increase in PMN phagocytosis, bactericidal capacity, hydrogen peroxide production, and percentage of cells with expression of surface receptor for Fc IgG. Superoxide anion production did not change significantly. Elevated temperature, stress, and anxiety were excluded as influences on our results.
Conclusion:
The PMN system is affected seriously by MR imaging.
Insights
Magnetic resonance (MR) imaging significantly impacts polymorphonuclear neutrophils (PMNs), enhancing their infection-fighting capabilities. This study reveals key changes in PMN function following MR imaging exposure.
Area of Science:
- Immunology
- Medical Imaging
Background:
- Limited research exists on the immunological effects of magnetic resonance (MR) imaging.
- No prior studies have investigated MR imaging's impact on the polymorphonuclear neutrophil (PMN) system.
Purpose of the Study:
- To evaluate the influence of MR imaging exposure on PMN function.
- To assess changes in PMN count, phagocytosis, and bactericidal capacity.
Main Methods:
- Conducted in vivo and in vitro studies on 36 patients undergoing MR imaging.
- Measured PMN count, phagocytosis, bactericidal capacity, and oxidative burst (superoxide, hydrogen peroxide).
- Assessed Fc IgG receptor expression and plasma lysozyme activity, controlling for temperature effects.
Main Results:
- MR imaging exposure decreased PMN count but enhanced phagocytosis and bactericidal capacity.
- Increased hydrogen peroxide production and Fc IgG receptor expression were observed.
- Superoxide anion production showed no significant change; temperature, stress, and anxiety were ruled out as factors.
Conclusions:
- The polymorphonuclear neutrophil (PMN) system is significantly affected by MR imaging.
- MR imaging appears to modulate PMN immune functions, warranting further investigation.