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Related Experiment Videos

Mastocytosis-induced nyctalopia

R L Lesser1, S E Brodie, S L Sugin

  • 1Department of Ophthalmology & Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA.

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
|June 1, 1996
PubMed
Summary
This summary is machine-generated.

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Systemic mastocytosis can cause night blindness due to vitamin A malabsorption. Prompt vitamin A therapy restored good vision in a patient with this rare condition.

Area of Science:

  • Ophthalmology
  • Hematology

Background:

  • Systemic mastocytosis involves increased mast cells, potentially affecting multiple organs.
  • Vitamin A deficiency can lead to visual impairment, including nyctalopia.

Observation:

  • A 55-year-old man with mastocytosis presented with nyctalopia (night blindness).
  • Diagnostic workup revealed low vitamin A levels and electroretinography (ERG) findings consistent with rod-cone deficiency.

Findings:

  • The patient's nyctalopia was attributed to malabsorption secondary to systemic mastocytosis.
  • Vitamin A supplementation successfully reversed the visual dysfunction.

Implications:

  • This is the first reported case of mastocytosis-induced nyctalopia.

Related Experiment Videos

  • Vitamin A deficiency should be considered in patients with mastocytosis experiencing sudden night blindness.