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Clara cell protein correlation with hyperlipidemia

H Nomori1, H Horio, M Takagi

  • 1Department of Surgery, Saiseikai Central Hospital, Tokyo, Japan.

Chest
|September 1, 1996
PubMed
Summary

Serum protein 1 (P1) levels correlate with various lipids and lipoproteins. P1 levels are significantly higher in obese individuals, indicating a link between P1 and obesity.

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Area of Science:

  • Biochemistry
  • Clinical Chemistry
  • Endocrinology

Background:

  • Protein 1 (P1), a Clara cell secretory protein, has an unclear role in metabolic health.
  • Understanding P1's associations with lipids and obesity is crucial for metabolic research.

Purpose of the Study:

  • To investigate the correlation between serum P1 levels and various serum lipids and lipoproteins.
  • To examine the relationship between P1 levels and body mass index (BMI), specifically in relation to obesity.
  • To compare P1 levels in patients with diabetes mellitus and atherosclerotic disease against healthy controls.

Main Methods:

  • Serum P1 levels were measured in 746 healthy subjects.
  • Correlations were analyzed between P1 levels and triglycerides (TG), total cholesterol (TCh), free cholesterol (FCh), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and apoproteins (apo A-I, A-II, B).
  • P1 levels were compared across different BMI categories (obese, normal, lean) and in patient groups (diabetes, atherosclerosis).

Main Results:

  • Serum P1 showed significant positive correlations with TG, TCh, FCh, apo A-I, apo A-II, apo B, and BMI.
  • A significant inverse correlation was observed between P1 and HDL levels.
  • Obese men exhibited significantly higher serum P1 levels compared to normal and lean men.
  • P1 levels did not significantly differ between diabetic or atherosclerotic patients and healthy controls.

Conclusions:

  • Serum P1 levels are significantly associated with various lipid and lipoprotein profiles.
  • Obesity is linked to elevated serum P1 levels, suggesting P1 as a potential marker for obesity-related metabolic changes.

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