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Related Experiment Videos

Tumor angiogenesis and interstitial hypertension

Y Boucher1, M Leunig, R K Jain

  • 1Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Boston 02114, USA.

Cancer Research
|September 15, 1996
PubMed
Summary

Tumor interstitial fluid pressure increases with new blood vessel growth (angiogenesis). Avascular tumors have normal pressure, while developing tumors show significant interstitial hypertension linked to neovascularization.

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Area of Science:

  • Oncology
  • Vascular Biology
  • Biophysics

Background:

  • Solid tumors exhibit high microvascular permeability, leading to interstitial hypertension.
  • Microvascular pressure (MVP) is a key driver of interstitial fluid pressure (IFP) in tumors.
  • The relationship between tumor angiogenesis and IFP requires further elucidation.

Purpose of the Study:

  • To investigate the correlation between tumor interstitial fluid pressure (IFP) and the development of tumor neovasculature.
  • To determine if IFP increases with tumor angiogenesis.

Main Methods:

  • Human colon adenocarcinoma (LS174T) and murine carcinoma (MCaIV) were implanted in mice using a dorsal skin fold chamber.
  • Tumor neovascularization was assessed via intravital microscopy across three stages: avascular (I), vascular sprouts/loops (II), and developed vasculature (III).

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  • Interstitial fluid pressure (IFP) was measured using micropipettes and a servo-null system; microvascular pressure (MVP) was also measured in some cases.

    • Main Results:

    • Avascular (Stage I) tumors exhibited IFP near 0 mm Hg.
    • IFP significantly increased with each successive stage of tumor neovascularization (Stage II and III).
    • LS174T spheroids, representing avascular tumors, showed minimal IFP (0.2 +/- 0.3 mm Hg).

    Conclusions:

    • Avascular tumors maintain pressures close to atmospheric levels.
    • Tumor interstitial hypertension is directly associated with the development and maturation of tumor neovasculature.
    • Understanding this relationship is crucial for targeted cancer therapies.