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Nafcillin entry into human cerebrospinal fluid

B E Fossieck, J G Kane, C R Diaz

    Antimicrobial Agents and Chemotherapy
    |June 1, 1977
    PubMed
    Summary
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    Nafcillin effectively enters human cerebrospinal fluid (CSF) without meningeal inflammation, reaching peak concentrations at 2 hours post-infusion. This antibiotic demonstrates sustained presence in the CSF for up to 4 hours.

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Infectious Diseases

    Background:

    • Cerebrospinal fluid (CSF) penetration is crucial for antibiotics targeting central nervous system infections.
    • Nafcillin is a penicillinase-resistant penicillin antibiotic commonly used for Staphylococcus infections.

    Purpose of the Study:

    • To quantify the penetration of nafcillin into the human cerebrospinal fluid (CSF) in the absence of meningeal inflammation.
    • To determine the pharmacokinetic profile of nafcillin in the CSF.

    Main Methods:

    • Twenty studies were conducted in 18 patients receiving intravenous sodium nafcillin (40 mg/kg over 30 min).
    • CSF and serum samples were collected at various time points (1, 2, 3, and 4 hours post-infusion).

    Main Results:

    Related Experiment Videos

    • Nafcillin was consistently detected in lumbar CSF starting at 1 hour post-infusion.
    • Peak nafcillin concentrations in CSF were observed at 2 hours post-infusion.
    • Detectable levels of nafcillin remained in the CSF of 75% of patients at 4 hours post-infusion.

    Conclusions:

    • Nafcillin exhibits significant penetration into the human CSF even without inflammation.
    • The pharmacokinetic data suggest nafcillin can achieve therapeutic concentrations in the CSF.
    • These findings support the potential utility of nafcillin for CNS infections where indicated.