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Serial MRI studies in pathologically verified Balò's concentric sclerosis
1Department of Radiology, Chang Gung Memorial Hospital, Medical College, Taipei, Taiwan.
Journal of Computer Assisted Tomography
|September 1, 1996
Summary
Serial MRI studies revealed characteristic concentric lesions in a patient with Balò's concentric sclerosis, aiding in diagnosis and tracking recovery from this rare demyelinating disease.
Area of Science:
- Neuroimaging
- Neurology
- Demyelinating Diseases
Background:
- Balò's concentric sclerosis is a rare, often rapidly progressive, demyelinating disease of the central nervous system.
- Accurate and timely diagnosis is crucial for appropriate management and prognosis.
- Magnetic Resonance Imaging (MRI) is a key tool in diagnosing white matter diseases.
Observation:
- A patient presented with progressive right-sided limb weakness over 10 days.
- Serial MRI revealed characteristic concentric lesions with alternating demyelinated and myelinated layers, alongside other white matter plaques.
- A biopsy of a concentric lesion confirmed the diagnosis of Balò's concentric sclerosis.
Findings:
- MRI demonstrated striking, layered concentric lesions mirroring histopathological findings of Balò's concentric sclerosis.
- The observed MRI features showed resolution correlating with clinical improvement.
- The patient achieved near-complete recovery within one year.
Implications:
- Serial MRI is invaluable for the antemortem diagnosis of Balò's concentric sclerosis.
- MRI findings can provide insights into disease activity and response to treatment.
- This case highlights MRI's role in differentiating rare demyelinating disorders.