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Intrauterine herpes simplex infections

J M Komorous, C E Wheeler, R A Briggaman

    Archives of Dermatology
    |July 1, 1977
    PubMed
    Summary

    Intrauterine herpes simplex virus (HSV) infections can cause severe congenital malformations. Differentiating between "early" and "late" intrauterine HSV infections based on malformation severity is proposed.

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    Meat science·2019

    Area of Science:

    • Virology
    • Neonatology
    • Teratology

    Background:

    • Neonatal herpes simplex virus (HSV) infections are well-documented.
    • Intrauterine HSV infections are less commonly recognized.
    • This study focuses on intrauterine HSV infections with congenital malformations.

    Observation:

    • Two new cases of intrauterine HSV infections with congenital malformations are presented.
    • Common features included intrauterine growth retardation, microcephaly, encephalitis, chorioretinitis, psychomotor retardation, and cutaneous vesicles.
    • Seven similar cases and cases without malformations were reviewed.

    Findings:

    • A classification is proposed: "early" intrauterine HSV for disturbed embryogenesis and "late" for less specific malformations.
    • The spectrum of intrauterine HSV infections may mirror that of neonatal infections.

    Implications:

    • Improved understanding and diagnosis of congenital HSV infections.
    • Potential for earlier intervention and management of affected neonates.
    • Highlights the importance of considering HSV in cases of congenital anomalies.

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