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Effects of the adjuvant MPL + TDM on tumor challenge in the B16 mouse melanoma model
J A Price1, J M McGee, M R Patten
1Department of Biochemistry and Microbiology, College of Osteopathic Medicine, Oklahoma State University, Tulsa 74107, USA.
International Journal of Immunopharmacology
|February 1, 1996
Abstract:
Mice were injected three times at 2 week intervals with the adjuvant MPL + TDM or phosphate-buffered saline. Two weeks after the last injection, all mice were challenged subcutaneously with a tumorgenic dose of B16 tumor and observed for 40 days. The adjuvant hastened the time at which tumors appeared (P = 0.02).