Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet PGI2 receptor affinity is reduced in pre-eclampsia

W Klockenbusch1, T Hohlfeld, M Wilhelm

  • 1Institut für Pharmakologie, Heinrich-Heine-Universität Düsseldorf, Germany.

British Journal of Clinical Pharmacology
|June 1, 1996
PubMed
Summary

Platelet prostacyclin (PGI2) receptors showed normal numbers in pre-eclampsia but reduced binding affinity. This finding may explain pregnancy-induced hypertension complications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Importance of acetylsalicylic acid in primary prevention : ASCEND, ARRIVE and ASPREE as well as a meta-analysis by Rothwell et al.]

Der Internist·2019
Same author

[Cardiovascular safety of celecoxib : Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen (PRECISION)].

Der Internist·2017
Same author

Why we should not skip aspirin in cardiovascular prevention.

Hamostaseologie·2015
Same author

Inhibition of antiplatelet effects of aspirin by nonopioid analgesics.

Clinical pharmacology and therapeutics·2015
Same author

[Aspirin and venous thromboses].

Der Internist·2015
Same author

[Perioperative aspirin treatment in patients undergoing surgery: Perioperative Ischemic Evaluation 2 (POISE-2)].

Der Internist·2014

Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Physiology
  • Pharmacology

Background:

  • Prostacyclin (PGI2) plays a crucial role in maintaining vascular homeostasis during pregnancy.
  • Pregnancy-induced hypertension (PIH) and pre-eclampsia are significant obstetric complications associated with vascular dysfunction.
  • Understanding PGI2 receptor function is vital for elucidating the pathophysiology of these conditions.

Purpose of the Study:

  • To investigate prostacyclin (PGI2) receptor characteristics in platelets of women with normal pregnancy, PIH, and pre-eclampsia.
  • To compare PGI2 receptor number and binding affinity across these pregnancy groups.

Main Methods:

  • Platelet membrane preparations were isolated from women in three groups: normal pregnancy, PIH, and pre-eclampsia.

Related Experiment Videos

  • Prostacyclin (PGI2) receptor number was quantified.
  • Binding affinity to the PGI2 mimetic iloprost was assessed.

    • Main Results:

    • No significant differences in gestational week at delivery were observed between the groups.
    • Patients with pre-eclampsia exhibited markedly lower birth weight compared to normal pregnancy and PIH groups.
    • Platelet PGI2 receptor number did not differ significantly across the groups.
    • A considerable reduction in binding affinity to iloprost was found in the pre-eclampsia group, while PIH and normal pregnancy groups showed similar receptor affinities.

    Conclusions:

    • Platelet PGI2 receptor number is not altered in pre-eclampsia or PIH.
    • Reduced binding affinity of PGI2 receptors in pre-eclampsia suggests impaired prostacyclin signaling, potentially contributing to the condition's pathophysiology.
    • These findings highlight a specific molecular alteration in pre-eclampsia, distinct from PIH, related to prostacyclin receptor function.