Season-specific thymic architecture in the frog, Rana temporaria: SEM studies

It is already known that the thymus of the adult common frog, Rana temporaria, undergoes conspicuous annual cyclic changes. Light microscopic (LM) observations are at present confirmed by three-dimensional scanning electron microscopy (SEM) pictures showing the presence of a characteristic cortico-medullary division of summer thymuses and cystic appearance of winter organs. Summer thymuses are larger, much heavier and populated by a significantly higher number of cells than winter organs. The season-specific thymic size, cell content and distribution are reflected by its angioarchitecture. The microcorrosion casts of vascular system of winter thymuses are much smaller and more compact than those of the summer organs in which vessels are arranged at larger spatial intervals. It seems that thymic enlargement following the winter atrophy results from vernal repopulation of the thymic cortex by thymocytes which in consequence induces a reshaping of the existing capillary network.