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Related Experiment Videos

Platelet methylene reductase activity in schizophrenia

P A Berger, G R Elliott, E Erdelyi

    Archives of General Psychiatry
    |July 1, 1977
    PubMed
    Summary

    Low activity of methylene reductase (N5-10-methylenetetrahydrofolate reductase) is not a common cause of schizophrenia. This study found no significant differences in enzyme activity between patients and controls, suggesting it

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    Area of Science:

    • Neuroscience
    • Biochemistry
    • Psychiatry

    Background:

    • A case study linked folate-responsive psychosis to N5-10-methylenetetrahydrofolate reductase (methylene reductase) deficiency.
    • This suggested a potential role for reduced methylene reductase activity in the etiology of schizophrenia.

    Purpose of the Study:

    • To investigate if reduced platelet methylene reductase activity is associated with chronic schizophrenia.
    • To determine the etiological significance of methylene reductase in schizophrenia.

    Main Methods:

    • Compared platelet methylene reductase activity in chronic schizophrenic patients.
    • Included hospitalized and non-hospitalized age-matched control subjects for comparison.

    Main Results:

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    • No statistically significant differences were found in platelet methylene reductase activity between chronic schizophrenics and control groups.
    • This indicates that reduced methylene reductase activity is not a general feature of chronic schizophrenia.

    Conclusions:

    • The study suggests that chronic schizophrenia is not typically associated with abnormally low methylene reductase activity.
    • While a subpopulation with enzyme defects cannot be ruled out, the findings do not support a widespread role for this enzyme deficiency in schizophrenia.