Model studies in tumor incidence

Two models of tumor incidence predicting the latency period as a function of the applied dose of a carcinogenic compound yield the same relationship as it has been empirically stated by Bryan and Shimkin (1,2). One model is based on a single-cell damage, the other one on a disturbtion of proliferation control within the cell population. The observed latency periods compared to the predicted values show that the tommunication model is a better basis for understanding chemical carcinogenesis than the single cell incidence.