Related Experiment Video
Updated: Aug 10, 2026

Recombineering Homologous Recombination Constructs in Drosophila
Published on: July 13, 2013
A note on the combination of estimates of a recombination fraction
Abstract:
A number of ways of combining two or more independent estimates of the same recombination fraction can be found in the literature. We revisit this topic in the context of human gene mapping, and explore the value of transforming the recombination fraction to a new parameter whose log-likelihood function is more nearly quadratic. It is shown that the arcsine of the cube-root is one such function. These observations lead naturally to a way of summarizing and combining the summarized set of log-likelihood functions of a common recombination fraction. This idea is illustrated using pedigree data concerning six loci on chromosome 10 from the CEPH consortium. A comparison is also made with the method of summarizing and combining using 'equivalent numbers' of recombinants and informative meioses.
More Related Videos
07:31Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
Published on: May 10, 2014
06:18Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR
Published on: July 11, 2025
Related Concept Videos
Hardy-Weinberg Principle
Gene Conversion
Overview of Transposition and Recombination
Conservative Site-specific Recombination and Phase Variation
The recognition sites for Cre recombinase called LoxP...
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Crossing Over