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Related Experiment Videos

'Routine' liver biopsy in upper abdominal surgery

S L Michel, R Lipsky, L Morgenstern

    Archives of Surgery (Chicago, Ill. : 1960)
    |August 1, 1977
    PubMed
    Summary

    Routine liver biopsy during upper abdominal surgery frequently reveals unsuspected liver disease. This safe procedure provides valuable diagnostic information for fatty metamorphosis, cholestasis, and other hepatic abnormalities.

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    Area of Science:

    • Gastroenterology and Hepatology
    • Surgical Pathology

    Background:

    • Undiagnosed hepatic abnormalities can complicate upper abdominal procedures.
    • The incidence and spectrum of occult liver findings are not well-established.

    Purpose of the Study:

    • To determine the incidence of unsuspected hepatic abnormalities via liver biopsy during upper abdominal operations.
    • To evaluate the safety and diagnostic utility of routine liver biopsy in this setting.

    Main Methods:

    • Liver biopsy specimens were collected from 125 consecutive patients undergoing upper abdominal surgery.
    • Histopathological examination identified various hepatic abnormalities, excluding pre-identified lesions.

    Main Results:

    • Sixty-seven percent of liver biopsies revealed abnormalities, including fatty metamorphosis, cholestasis, triaditis, fibrosis, and hepatitis.
    • Abnormalities were found in 51% of patients with chronic cholecystitis and 78% with acute cholecystitis.
    • Eighty-three percent of other upper abdominal operations showed abnormal liver histology.

    Conclusions:

    • Liver biopsy is a safe and informative adjunct to upper abdominal procedures.
    • Routine liver biopsy can detect a high incidence of occult hepatic lesions.
    • Future advancements in histochemical and electron microscopy may further elucidate occult hepatic pathology.

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