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Related Experiment Videos

Aspergillus and lung transplantation

V Yeldandi1, F Laghi, M A McCabe

  • 1Department of Medicine, Stritch School of Medicine, Loyola University Medical Center, Maywood, Ill. 60153, USA.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|September 1, 1995
PubMed
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Lung transplant recipients face a high risk of Aspergillus infection. While locally invasive cases responded to antifungal treatment, disseminated disease proved fatal, highlighting the need for preventative strategies.

Area of Science:

  • Medical Mycology
  • Transplantation Medicine
  • Infectious Diseases

Background:

  • Aspergillus infection is a recognized complication following organ transplantation.
  • Lung transplant recipients are particularly susceptible to fungal infections.

Purpose of the Study:

  • To analyze the incidence, clinical manifestations, and outcomes of Aspergillus infections in lung transplant recipients.
  • To identify risk factors associated with invasive aspergillosis in this patient population.

Main Methods:

  • Retrospective review of 37 lung transplant patients over two years.
  • Categorization of patients based on clinical manifestations of Aspergillus infection (culture or biopsy evidence).
  • Analysis of risk factors compared to other transplant recipients.

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Main Results:

  • The incidence of invasive aspergillosis was 16% among lung transplant recipients.
  • Disseminated Aspergillus disease resulted in mortality for all affected patients.
  • Locally invasive disease showed positive response to amphotericin B and itraconazole treatment.

Conclusions:

  • Lung transplant recipients may exhibit a higher incidence of aspergillosis compared to other transplant groups.
  • Effective prophylactic measures against Aspergillus infection in lung transplant candidates and recipients require further investigation.
  • Early diagnosis and targeted antifungal therapy are crucial for managing locally invasive disease.