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The effect of recombination on background selection

M Nordborg1, B Charlesworth, D Charlesworth

  • 1Department of Ecology & Evolution, University of Chicago, IL 60637-1573, USA. magnus@darwin.uchicago.edu

Genetical Research
|April 1, 1996
PubMed
Summary

Background selection, driven by linked deleterious mutations, impacts genetic variability. This study derives an equation to predict these effects, validated by simulations across various conditions.

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Area of Science:

  • Population Genetics
  • Evolutionary Biology
  • Molecular Evolution

Background:

  • Background selection, caused by linked deleterious mutations, can reduce genetic variation.
  • Understanding these effects is crucial for interpreting patterns of genetic diversity within populations.

Purpose of the Study:

  • To derive and validate an approximate equation predicting the impact of background selection on genetic variability.
  • To explore how linkage, selection coefficients, and recombination influence these effects.

Main Methods:

  • Derivation of an approximate mathematical equation for background selection.
  • Monte Carlo computer simulations to test the equation's validity under diverse conditions.

Main Results:

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  • The derived equation accurately predicts background selection effects across various genetic maps and selection coefficient distributions.
  • Simulations confirm the formula's robustness, even with epistatic fitness interactions, except under very weak selection and tight linkage.
  • Weakly selected mutations show greater potential for regional variability patterning along chromosomes.

Conclusions:

  • Background selection can significantly reduce genetic variation, particularly in organisms with small chromosome numbers and short genetic maps like Drosophila.
  • Species with high recombination rates, such as mammals, are less susceptible to large-scale reductions, but local effects in low-recombination regions may be observable.