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Early olfactory enrichment and deprivation both decrease beta-adrenergic receptor density in the main olfactory bulb

C C Woo1, M Leon

  • 1Department of Psychobiology, University of California, Irvine 92717, USA.

The Journal of Comparative Neurology
|October 2, 1995
PubMed
Summary

Early olfactory experiences, like deprivation or enrichment, alter beta-adrenergic receptor density in the rat olfactory bulb. These changes may involve norepinephrine signaling in the olfactory bulb.

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Area of Science:

  • Neuroscience
  • Sensory Biology
  • Receptor Pharmacology

Background:

  • Noradrenergic locus coeruleus projections and beta-adrenergic receptors are present in the rat main olfactory bulb.
  • These receptors exhibit laminar distributions and focal high-density regions within glomeruli, sites of initial synaptic contact.

Purpose of the Study:

  • To investigate the impact of early olfactory deprivation and enrichment on beta-adrenergic receptor density and distribution in the main olfactory bulb.
  • To understand how sensory experiences influence neurochemical adaptations in the olfactory system.

Main Methods:

  • Quantitative autoradiography was employed using specific beta-adrenergic receptor antagonists ([125I]iodopindolol, ICI 118,551, ICI 89,406).
  • Animals underwent either unilateral naris closure (olfactory deprivation) or odor training (olfactory enrichment) from postnatal days 1-18.

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Main Results:

  • Unilateral naris closure reduced beta 2 glomerular foci and the density of beta 1 and beta 2 receptors in the deprived olfactory bulb.
  • Early odor training decreased the number, area, and density of beta 2 glomerular foci in specific regions of the olfactory bulb.

Conclusions:

  • Early olfactory experiences, including deprivation and enrichment, significantly alter beta-adrenergic receptor density and distribution in the main olfactory bulb.
  • These sensory-driven changes may be mediated by transient increases in olfactory bulb norepinephrine levels.