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Foreign-body reaction to absorbable fixation devices

J Frederick, T J Hulst, A S Sundareson

    Journal of the American Podiatric Medical Association
    |August 1, 1996
    PubMed
    Summary
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    Orthosorb pins, made from poly-p-dioxanon, can still cause foreign-body reactions despite being less reactive than polyglycolide. This highlights potential inflammatory responses with certain biodegradable polymers.

    Area of Science:

    • Biomaterials Science
    • Polymer Chemistry
    • Surgical Implant Research

    Background:

    • Biodegradable polymers like poly-p-dioxanon and polyglycolide are widely used in medical devices.
    • Polyglycolide is known to elicit a foreign-body reaction, prompting the development of less reactive alternatives.
    • Poly-p-dioxanon was developed as a potentially less reactive alternative to polyglycolide for surgical applications.

    Observation:

    • Recent studies indicate that Orthosorb pins, composed of poly-p-dioxanon, are associated with foreign-body reactions.
    • These reactions are similar to those observed with Biofix products, despite the presumed lower reactivity of poly-p-dioxanon.
    • The observed inflammatory response challenges the assumption of complete inertness for poly-p-dioxanon in vivo.

    Findings:

    Related Experiment Videos

    • Poly-p-dioxanon exhibits a degree of reactivity leading to foreign-body responses in the context of Orthosorb pins.
    • The reactivity of poly-p-dioxanon, while less than polyglycolide, is sufficient to trigger an inflammatory cascade.
    • Foreign-body reactions can occur with various biodegradable polymers, necessitating careful material selection and monitoring.

    Implications:

    • The findings suggest a need for re-evaluation of poly-p-dioxanon's biocompatibility and long-term tissue response.
    • Clinical implications include potential complications related to inflammation and implant integration with Orthosorb devices.
    • Further research is warranted to understand the mechanisms of foreign-body reaction to poly-p-dioxanon and optimize implant design.