Related Experiment Video
Updated: Aug 14, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Malignant lymphomas with a follicular growth pattern
1Department of Histopathology, University College London Medical School, UK.
Abstract:
Given the pivotal role of the B-cell follicle in B-cell proliferation, and the fact that the follicle centre has the highest proliferation fraction of any structure in the body, it would be reasonable to expect that the potential for the development of aberrant (neoplastic) growth within it would be relatively high, especially when compared to other lymphoid compartments. However, in all current lymphoma classifications only one entity, namely follicular lymphoma, is acknowledged as having any relation to the follicle. As knowledge of the immunophenotype and function of the normal follicle has increased, it has become evident that many lymphomas, including some examples of Hodgkin's disease, are related to the B-cell follicle and as a consequence manifest a follicular growth pattern. This has implications for the pathogenesis of these tumours and may point the way to novel therapeutic options.
Related Concept Videos
Abnormal Proliferation
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Abnormal Proliferation
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Folliculogenesis

