Related Experiment Video
Updated: Oct 9, 2026

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
A possible tumor suppressor gene for parathyroid adenomas
1First Department of Surgery, Yokohama City University School of Medicine, Japan.
Abstract:
Many short sequence repeat polymorphisms (SSRP) have been reported recently. There have been few reports of loss of heterozygosity (LOH) in tumors, employing these SSRP markers. The author examined loss of heterozygosity in 19 MEN-1 tumors and 43 sporadic parathyroid adenomas. All 19 (100%) MEN-1 tumors showed allelic loss on chromosome 11q. 15 out of 43 (34.9%) sporadic parathyroid adenomas showed allelic loss at the same locus on chromosome 11 as MEN-1 tumors. There was no significant allelic loss region on other chromosomes. These results suggest that the MEN-1 gene, which plays the role of a tumor suppressor gene in parathyroid tissue, has been localized telomeric to PYGM and centromeric INT2 loci on chromosome 11q13 and that the MEN-1 gene can be a tumor suppressor gene for sporadic parathyroid adenomas.
Related Concept Videos
Abnormal Proliferation
Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...

