Biophysical shunt theory for neuropsychopathology. Part II: Neuronal network miswiring

Neuronal networks have become recognized in neuroscience as the backbone of information-processing by virtue of their dynamics and their relationship to biocommunication to defined targets. Their patterns of activity and regulation derive from the final architecture of the associated neurons, each with its distinct network and working regimen. These networks are spatially localized in the brain, adhere to temporal, fixed bonds and have a definite unit specification. This article focuses primarily on the vast amount of data concerning normal neuronal networks which can produce collateral pathways to compensate for the loss of innervation of adjacent cells. It is suggested that, under abnormal conditions such mechanisms may cause 'miswiring' leading to a fundamental bypass in neuroconduction, misguided biosignal orientation, direction and distribution, and culminating in misinformation. This re-establishment of complementary neuronal networks is manifested in recognizable neuropsychopathological states.