Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cannabinoid receptor genes

E S Onaivi1, A Chakrabarti, G Chaudhuri

  • 1Department of Pharmacology, Meharry Medical College, Nashville, TN 37208, USA.

Progress in Neurobiology
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of increasing doses of a phytogenic product based on condensed tannins and spices on production performance and rumen microbiome of lactating dairy cows fed a low-protein diet.

Journal of dairy science·2026
Same author

Edible bamboo shoots: a sustainable nexus of nutrition, livelihood, and food security for rural communities in India.

Frontiers in nutrition·2025
Same author

Evaluation of hospital environment for presence of Mucorales during COVID-19-associated mucormycosis outbreak in India - a multi-centre study.

The Journal of hospital infection·2022
Same author

Grain size dependence of optical properties and positron annihilation parameters in Bi<sub>2</sub>O<sub>3</sub>powder.

Nanotechnology·2021
Same author

Adverse childhood experiences and substance misuse in young people in India: results from the multisite cVEDA cohort.

BMC public health·2021
Same author

Intraosseus route for thrombolysing acute stroke is safe and successful.

QJM : monthly journal of the Association of Physicians·2021
Same journal

Deletion of Fbxo25 causes excessive repetitive behavior, impaired recognition memory, reduced dendritic complexity, and aberrant protein expression in mice.

Progress in neurobiology·2026
Same journal

Neuropsychiatric Disease Mechanisms and Interventions. from 22q11.2 Deletion Syndrome Experimental Studies.

Progress in neurobiology·2026
Same journal

REM sleep as a dummy-model of the world: A theoretical framework.

Progress in neurobiology·2026
Same journal

CA3 transiently modulates spatial representation in CA1.

Progress in neurobiology·2026
Same journal

Love, death, and oxytocin: In memory of Larry Young.

Progress in neurobiology·2026
Same journal

Assessing peripheral oxytocin and cortisol levels and epigenetic variations of oxytocin receptor and glucocorticoid receptor genes in school-aged preterm-born children.

Progress in neurobiology·2026
See all related articles

Recent advances in marijuana research include identifying cannabinoid receptors and anandamide, an endogenous substance with neurotransmitter potential. These discoveries enhance our understanding of cannabis sativa's effects.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Molecular Biology

Background:

  • Cannabinoids, derived from cannabis sativa, have a long history of use but limited scientific understanding.
  • Research was historically constrained by a lack of specific molecular tools and technology.
  • Recent technological advancements have accelerated progress in understanding marijuana's effects.

Purpose of the Study:

  • To summarize recent breakthroughs in cannabinoid research.
  • To highlight the identification of cannabinoid receptors and endogenous ligands.
  • To discuss the implications for understanding the neurobiology of cannabis.

Main Methods:

  • Cloning of cDNA sequences for peripheral and central nervous system cannabinoid receptors (CB1 and CB2).
  • Isolation and characterization of anandamide, a putative endogenous cannabinoid ligand.

Related Experiment Videos

  • Development of selective antagonists for cannabinoid receptors.

    • Main Results:

    • Successful cloning of cannabinoid receptors from multiple species (rat, human, mouse).
    • Identification of anandamide in the brain, suggesting an endogenous cannabinoid system.
    • Anandamide exhibits properties indicative of a neuromodulatory or neurotransmitter role.
    • Development of potent and selective CB1 receptor antagonists.

    Conclusions:

    • The discovery of anandamide opens a new neurochemical system for study.
    • Cannabinoid research is rapidly advancing, offering insights into physiological and neurobehavioral effects.
    • Future research directions include antisense strategies and gene targeting to elucidate cannabinoid mechanisms of action.