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Association study between schizophrenia and monoamine oxidase A and B DNA polymorphisms
B Coron1, D Campion, F Thibaut
1Groupe de Recherche sur la Schizophrénie, Université de Rouen, Centre Hospitalier Spécialisé du Rouvray, Sotteville Les Rouen, France.
Psychiatry Research
|June 1, 1996
Summary
Genetic variations in Monoamine Oxidase (MAO) genes were studied in schizophrenia. Researchers found no significant association, suggesting MAO gene variants may not be a major factor in schizophrenia predisposition.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Monoamine oxidases (MAO) A and B are crucial for dopamine metabolism.
- Reduced MAO-B activity is observed in schizophrenia patients.
- Genetic variations in MAO activity are hypothesized to contribute to schizophrenia etiology.
Purpose of the Study:
- To investigate the association between intragenic polymorphisms in MAO-A and MAO-B genes and schizophrenia.
- To determine if genetic variants in MAO genes play a significant role in schizophrenia predisposition.
Main Methods:
- An association study was conducted using two intragenic polymorphisms within the MAO-A and MAO-B genes.
- The study included 110 schizophrenic patients and 87 control subjects.
Main Results:
- No significant differences in allelic frequencies were found between patients and controls for either MAO-A or MAO-B polymorphic markers.
- A trend towards an association between MAO-B gene allele 1 and paranoid schizophrenia was observed.
Conclusions:
- The study's findings do not support the hypothesis that inherited variants of MAO genes are a major factor in schizophrenia predisposition.
- Further research identifying polymorphisms related to MAO-B enzyme activity is warranted, given previous reports of low MAO-B activity in paranoid schizophrenia patients.