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Glutathione deficiency as a complication of methylmalonic acidemia: response to high doses of ascorbate
E Treacy1, L Arbour, P Chessex
1Biochemical Genetics Unit, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.
The Journal of Pediatrics
|September 1, 1996
Abstract:
A 7-year-old boy with deficient activity of methylmalonyl coenzyme A mutase (mut-methylmalonic acidemia) was seen in severe metabolic crisis. After hemodialysis and clearance of toxic metabolites, severe lactic acidosis persisted with multiorgan failure. Glutathione deficiency was noted and high-dose ascorbate therapy (120 mg/kg) commenced. Glutathione deficiency may contribute to the lactic acidosis observed during decompensation in patients with methylmalonic acidemia.