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Solution-phase generation of tetraurea libraries
G W Shipps1, U P Spitz, J Rebek
1Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
Bioorganic & Medicinal Chemistry
|May 1, 1996
Abstract:
Libraries of tetraureas tethered to a rigid core have been assembled. This simple, solution-phase methodology generates a defined, anticipated distribution of compounds. These conclusions are supported by synthesizing pure (homo) tetraurea xanthenes and by HPLC analysis of small 'microlibraries'.