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Related Experiment Videos

Modulating L-type calcium current affects discontinuous cardiac action potential conduction

R W Joyner1, R Kumar, R Wilders

  • 1Todd Franklin Cardiac Research Laboratory, Children's Heart Center, Department of Pediatrics, Emory University, Atlanta, Georgia 30322, USA. rjoyner@anatomy.emory.edu

Biophysical Journal
|July 1, 1996
PubMed
Summary
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Cardiac cell coupling affects action potential conduction. Isoproterenol and BayK 8644 modulate L-type calcium current to improve conduction in cells with low coupling or size differences.

Area of Science:

  • Cardiovascular physiology
  • Computational biology
  • Pharmacology

Background:

  • Cardiac action potential conduction relies on cell-to-cell coupling.
  • Heterogeneity in cell size and coupling conductance can impede conduction.
  • L-type calcium current plays a crucial role in cardiac electrophysiology.

Purpose of the Study:

  • To investigate the impact of variable coupling conductance and L-type calcium current modulation on cardiac action potential conduction.
  • To determine how agents affecting L-type calcium current influence conduction delays caused by reduced coupling or cell size asymmetry.

Main Methods:

  • Used pairs of real guinea pig ventricular cells and simulated models.
  • Applied direct stimulation to a 'leader' cell to assess action potential propagation to a 'follower' cell.

Related Experiment Videos

  • Administered isoproterenol, BayK 8644 (calcium current enhancer), and nifedipine (calcium current blocker).

    • Main Results:

    • Decreased coupling conductance or larger follower cells significantly delayed action potential conduction.
    • Isoproterenol and BayK 8644 reduced critical coupling conductance and increased allowable cell size asymmetry, improving conduction.
    • Nifedipine produced opposite effects, worsening conduction delays.

    Conclusions:

    • Modulation of L-type calcium current by isoproterenol and BayK 8644 can rescue conduction in conditions of reduced coupling or cell size mismatch.
    • These findings suggest that drugs targeting L-type calcium current may be effective in treating cardiac conditions with discontinuous conduction.