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Conditioned taste aversion induced by fluoxetine

M A Prendergast1, S E Hendricks, D P Yells

  • 1University of Nebraska at Omaha, Department of Psychology 68182, USA.

Physiology & Behavior
|July 1, 1996
PubMed
Summary

Serotonin reuptake inhibitor fluoxetine (FLX) and lithium chloride (LiCl) effectively induced conditioned taste aversion (CTA) in rats. This aversion was independent of drug-induced reductions in food or water intake, suggesting a distinct aversive mechanism.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine (FLX) are widely prescribed.
  • Understanding drug-induced taste aversion is crucial for managing side effects and therapeutic applications.
  • Lithium chloride (LiCl) is a well-established agent for inducing conditioned taste aversion (CTA).

Purpose of the Study:

  • To investigate the capacity of fluoxetine (FLX) to elicit conditioned taste aversion (CTA) in rats.
  • To compare the CTA-inducing effects of FLX with those of lithium chloride (LiCl).
  • To determine if FLX-induced CTA is mediated by general reductions in food or water consumption (hypophagia/hypodipsia).

Main Methods:

  • Rats were exposed to a novel sucrose solution and subsequently administered varying doses of FLX or LiCl.

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  • Conditioned taste aversion was assessed by measuring sucrose solution consumption 24 hours later.
  • Separate experiments evaluated the direct effects of FLX on sucrose consumption without prior taste exposure to rule out hypophagia.

    • Main Results:

    • Both FLX (at all tested doses) and LiCl significantly reduced sucrose solution intake, indicating CTA.
    • FLX did not suppress sucrose consumption when administered without prior taste exposure, ruling out dose-dependent hypophagia or hypodipsia as the primary cause of CTA.
    • The results suggest FLX acts as a potent conditioned stimulus for CTA, similar to LiCl.

    Conclusions:

    • Fluoxetine effectively induces conditioned taste aversion in rats, comparable to lithium chloride.
    • The aversion learned is a result of an aversive drug state, not a general decrease in appetite or thirst.
    • These findings have implications for understanding and managing potential side effects of fluoxetine treatment.