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Identification of the GABAA receptor alpha-subunit mRNA in rat intestine
D K Zeiter1, X Li, D L Broussard
1Division of Gastroenterology and Nutrition, Children's Hospital of Philadelphia, PA 19104, USA.
Brain Research. Molecular Brain Research
|July 1, 1996
Abstract:
We investigated the expression of gamma-aminobutyric acid type A (GABAA) receptor alpha 1-, alpha 2- and alpha 3-subunit mRNAs in the rat intestine using reverse transcription and polymerase chain reaction. alpha 1- and alpha 3-, but not alpha 2-, subunit mRNAs were amplified from the proximal intestine, ileum, and colon. In-situ hybridization studies demonstrated the expression of alpha 1-subunit mRNA by myenteric neurons. GABA may be active via the GABAA receptor in the enteric nervous system.