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Protein sequence motifs

P Bork1, E V Koonin

  • 1European Molecular Biology Laboratory, Heidelberg, Germany. bork@embl-heidelberg.de

Current Opinion in Structural Biology
|June 1, 1996
PubMed
Summary
This summary is machine-generated.

Protein sequence motifs aid in predicting protein function, with a trend towards analyzing structural and regulatory proteins. Systematic motif databases from genome sequencing enable classification of new protein sequences.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Molecular Biology

Background:

  • Protein sequence motifs serve as crucial identifiers for protein families and are valuable tools for predicting protein function.
  • Current research trends focus on generalizing and modifying known motifs, alongside the ongoing discovery of novel ones.
  • The focus of motif analysis is shifting from easily recognizable motifs in metabolic enzymes to more divergent motifs in structural and regulatory proteins.

Purpose of the Study:

  • To highlight the evolving trends in protein motif analysis.
  • To emphasize the increasing importance of structural information in motif identification.
  • To propose the feasibility of creating systematic motif databases for protein sequence classification.

Main Methods:

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  • Review of current literature on protein motif analysis trends.
  • Discussion of the role of structural information in motif discovery and sensitivity.
  • Exploration of genome sequencing data for systematic motif identification.

    • Main Results:

    • Motif analysis is increasingly applied to structural and regulatory proteins, which possess more diverse motifs.
    • Structural information is becoming more integral to identifying motifs and assessing their sensitivity.
    • Systematic analysis of motifs across an organism's genome is feasible, enabling the creation of comprehensive motif databases.

    Conclusions:

    • Systematic motif databases derived from genomic data can facilitate the classification of a large proportion of newly identified protein sequences.
    • The shift towards analyzing divergent motifs in structural and regulatory proteins necessitates advanced identification methods.
    • Protein motif analysis remains a dynamic field with significant implications for understanding protein function and biological systems.