Thermodynamics of base pairing
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Updated: Aug 11, 2026

Measuring Biomolecular DSC Profiles with Thermolabile Ligands to Rapidly Characterize Folding and Binding Interactions
Published on: November 21, 2017
1Department of Chemistry, University of Rochester, NY 14627-0216, USA. turner@chem.chem.rochester.edu
Abstract:
The study of the thermodynamics of base pairing is a rapidly expanding field due to its importance for taking advantage of opportunities presented by the growing database of nucleic acid sequences. Both natural and unnatural nucleic acids are being studied. The determination of nearest-neighbor parameters from optical melting data for RNA-DNA and DNA-DNA duplexes with Watson-Crick base pairs is particularly noteworthy. The foundations are also being laid for a theoretical understanding of these thermodynamics.
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