Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Danger - pathogen on the premises! Immunological tolerance

C A Janeway1, C C Goodnow, R Medzhitov

  • 1Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

Current Biology : CB
|May 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The selection of self-MHC recognizing T lymphocytes: a role for idiotypes?

Immunology today·2014
Same author

T-cell regulation of IgA responses.

Immunology today·2014
Same author

Through a glass, darkly ….

Immunology today·2014
Same author

Quantitative variation in la antigen expression plays a central role in immune regulation.

Immunology today·2014
Same author

T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2- and I-A restricted.

Immunogenetics·2012
Same author

The immunological system of the child: part I: development of immunity in the child.

Archives of disease in childhood·2010
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

Recent findings demonstrate that immune responses can be induced in newborn mice. This challenges the long-held belief that the immune system

Area of Science:

  • Immunology
  • Developmental Biology

Background:

  • The traditional view posits that the immune system's ability to distinguish "self" from "non-self" is innate.
  • Neonatal immunity is considered a critical period for immune system development and tolerance induction.

Purpose of the Study:

  • To investigate whether immune responses can be elicited in neonatal mice.
  • To evaluate the implications of these findings for the established "self"-"non-self" discrimination model.

Main Methods:

  • Induction of immune responses in neonatal mouse models.
  • Analysis of immune cell activation and cytokine production.
  • Assessment of immune tolerance development.

Main Results:

  • Demonstration of successful induction of immune responses in neonatal mice.

Related Experiment Videos

  • Evidence suggesting a more dynamic immune system in early life than previously assumed.
  • Observations that challenge the strict "self"-"non-self" paradigm in neonates.

    • Conclusions:

    • Neonatal immune responses can be induced, questioning the absolute nature of "self"-"non-self" discrimination at birth.
    • These findings suggest a potential window for immune modulation in early life.
    • Re-evaluation of neonatal immune development and tolerance mechanisms is warranted.