Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inositol phosphates - whither bound? Intracellular signalling

R Irvine1, P Cullen

  • 1Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, UK.

Current Biology : CB
|May 1, 1996
PubMed
Summary

Researchers are discovering many proteins that bind inositol phosphates. While diverse binding domains suggest convergent evolution, the specific functions of most inositol phosphate binding sites remain unclear.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A remotely-delivered pilot and feasibility program to promote physical and food literacy in adolescents with intellectual disabilities.

Journal of applied research in intellectual disabilities : JARID·2024
Same author

Mr. Cullen on White Serum.

The Medical and physical journal·2018
Same author

Case of Splenitis Acutus.

Edinburgh medical and surgical journal·2018
Same author

Mesmerism (?).

The Indian medical gazette·2017
Same author

Dispensary Midwifery Practice.

The Indian medical gazette·2017
Same author

Experiments with Carbolic Acid.

The Indian medical gazette·2017

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Signaling

Background:

  • Inositol phosphates (IPs) are crucial second messengers in cellular signaling pathways.
  • A growing number of proteins are identified as IP-binding proteins.
  • The diversity of IP-binding domains is notable.

Purpose of the Study:

  • To review the current understanding of protein-inositol phosphate interactions.
  • To explore the implications of diverse binding domains in the context of evolution.
  • To highlight the knowledge gaps regarding the functional roles of these binding sites.

Main Methods:

  • Literature review of studies on protein-IP interactions.
  • Analysis of protein domain structures and evolutionary patterns.

Related Experiment Videos

  • Synthesis of current functional data on IP-binding proteins.

    • Main Results:

    • Numerous proteins exhibit specific or non-specific binding to various inositol phosphate molecules.
    • The presence of multiple distinct domains capable of binding IPs suggests convergent evolution across different protein families.
    • Functional characterization of most identified IP-binding sites is lacking.

    Conclusions:

    • The widespread occurrence of IP-binding proteins underscores their importance in cellular processes.
    • Convergent evolution has shaped diverse protein architectures for IP recognition.
    • Further research is essential to elucidate the precise biological functions mediated by these numerous inositol phosphate binding sites.