Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The cell-death machine

A M Chinnaiyan1, V M Dixit

  • 1University of Michigan Medical School, Department of Pathology, 1301 Catherine Street, Box 0602, Ann Arbor, Michigan 48109, USA.

Current Biology : CB
|May 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular profiling of ETS and non-ETS aberrations in prostate cancer patients from northern India.

The Prostate·2021
Same author

MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer.

Oncogene·2016
Same author

Frequent PD-L1 expression in primary and metastatic penile squamous cell carcinoma: potential opportunities for immunotherapeutic approaches.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

The 7th Barossa Meeting--Cell Signalling in Cancer Biology and Therapy in Barossa Valley, Australia.

Cell death & disease·2016
Same author

Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015.

Annals of oncology : official journal of the European Society for Medical Oncology·2015
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

Programmed cell death, or apoptosis, is vital for development and homeostasis. Researchers are identifying genes involved in apoptosis, but the precise protein interactions in this cell-death pathway require further investigation.

Area of Science:

  • Cell biology
  • Molecular biology
  • Developmental biology

Background:

  • Apoptosis, or programmed cell death, is a fundamental physiological process.
  • It is essential for maintaining homeostasis and enabling proper metazoan development.
  • Recent advancements have identified numerous genes implicated in the apoptotic pathway.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying apoptosis.
  • To understand the roles of newly identified genes in programmed cell death.
  • To investigate the interactions between various proteins involved in the cell-death machinery.

Main Methods:

  • Gene identification and characterization.
  • Protein interaction studies.
  • Molecular pathway analysis.

Related Experiment Videos

Main Results:

  • Identification of multiple genes involved in apoptosis.
  • Categorization of genes as encoding death effectors or regulators (positive/negative).
  • Evidence suggesting complex protein interactions within the apoptotic pathway.

Conclusions:

  • Programmed cell death is a complex process regulated by numerous genes.
  • Further research is needed to fully map the protein interaction network governing apoptosis.
  • Understanding these interactions is crucial for comprehending cell fate determination.